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Monday, May 26, 2008

11, 17 or 21 alpha-hydroxylase deficiencies

Let's keep this real short and sweet and hopefully easy to remember.

21 alpha-hydroxlase deficiency: (masculinization, pseudohermaphrodite) 
the most common congenital adrenal hyperplasia syndrome
Key feature = Hypotension and dehydration (salt wasting)

11 alpha-hydroxlase deficiency: (Masculinization)
Key feature used to distinguish 11 from 21 = hypertension due to increased mineralcorticoids

17 alpha-hydroxylase deficiency: (fails to mature sexually)
phenotypical female but never matures = no sex hormones = this distinguishes it from 11 because 17 has increased mineralcorticoids and hypertension as well. 

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