Friday, May 23, 2008

Dopamine, Dopamine, Dopamine

D1, D2, D3, D4, D5

So lets say runners D1, D2, D3, D4, D5 are all in a marathon. The 1st and last place are the most excitatory positions. Everyone wants to be in first place (D1) so they are motivated (excitatory) to run faster. No one wants to be in last place (D5), so they are motivated (excitatory) to run faster so they are not last. This will help you remember that: D1 & D5 are excitatory and the rest (D2, D3, D4) are inhibitory.

Excitatory:
D1 & D5
Stimulate kidney during shock

Inhibitory:
D2, D3 & D4 The schizophrenic drugs act on D2 which inhibits dopamine

Dopamine works on G protein cAMP 2nd messengers 

Back to the runner analogy. Imagine that many runners are also love the outdoors so they also like to camp. This should remind you that cAMP is the 2nd messenger of dopamine.

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