Stomach Acid and H2

H2 blockers:

Mechanism:

Reversible block of histamine H2 receptors = decreases H+ secretion by parietal cells

Uses:

Peptic ulcer, gastritis, mild esophogeal reflux

Issues:

The main drug you need to remember for boards is Cimetidine

Inhibits P-450 

Antiandrogenic effects = prolactin release, gynecomastia etc.

Decrease renal excretion of creatinine