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Saturday, May 24, 2008

Osteoblastic or Osteolytic

Ok you need to know which cancers are Osteolytic and which are osteoblastic.
Osteolytic = breaks bone down so osteoclasts are involved and enzymes like IL-1 and PGE2 are involved and stimulate the osteoclasts. Patient often has hypecalcemia. 
Osteoblastic = builds bone so like the name suggests, osteoblasts are involved. The Alkaline Phosphatase would be elevated.

Lung = lytic
Prostate = Blastic
Breast = Both lytic and blastic
Multiple Myeloma = Lytic (cookie cutter lesions) 

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