Ectopic Forensics

Patient presents with: Hyponatremia or Cushings, What cancer do you think of?

Small Cell Carcinoma (S100 marker, neural crest origin) 

Ectopic ADH causes Hyponatremia

ACTH causes Cushings

Hypocalcemia or Secondary Polycythemia?

Renal Adenocarcinoma

PTH-like peptide causes hypercalcemia 

Erythropoietin causes secondary polycythemia 

Hypoglycemia or Secondary Polycythemia?

Hepatocellular Carcinoma

Insulin-like factor = Hypoglycemia

Erythropoietin = Secondary Polycythemia

Hypocalcemia?

Medullary Carcinoma of the Thyroid

Calcitonin = tumor marker get turned into amyloid so it can no longer stimulate osteoclasts to break bone down = hypocalcemia

Shout out to Goljin